|
Osteoporosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Women with the TT genotype in rs1883832 SNP affecting to Kozak consensus sequence of CD40 gene had lower BMD at FN and at LS sites and increased risk of osteopenia or osteoporosis.
|
18097708 |
2008 |
|
Osteopenia
|
|
0.010 |
GeneticVariation
|
BEFREE |
Women with the TT genotype in rs1883832 SNP affecting to Kozak consensus sequence of CD40 gene had lower BMD at FN and at LS sites and increased risk of osteopenia or osteoporosis.
|
18097708 |
2008 |
|
Multiple Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
We investigated the cell specific gene and protein expression variation controlled by the CD40 genetic variant(s) associated with MS, i.e. the T-allele at rs1883832.
|
26068105 |
2015 |
|
Adult Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We hypothesized that single nucleotide polymorphisms (SNPs) in TNFRSF5 and TNFSF5 encoding the CD40 and CD154 proteins, respectively, influence lymphoma risk, particularly a functional TNFRSF5 SNP (-1C>T, rs1883832) associated with reduced B-cell CD40 expression.
|
18287517 |
2008 |
|
Childhood Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We hypothesized that single nucleotide polymorphisms (SNPs) in TNFRSF5 and TNFSF5 encoding the CD40 and CD154 proteins, respectively, influence lymphoma risk, particularly a functional TNFRSF5 SNP (-1C>T, rs1883832) associated with reduced B-cell CD40 expression.
|
18287517 |
2008 |
|
Lymphoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We hypothesized that single nucleotide polymorphisms (SNPs) in TNFRSF5 and TNFSF5 encoding the CD40 and CD154 proteins, respectively, influence lymphoma risk, particularly a functional TNFRSF5 SNP (-1C>T, rs1883832) associated with reduced B-cell CD40 expression.
|
18287517 |
2008 |
|
Autoimmune Diseases
|
|
0.020 |
GeneticVariation
|
BEFREE |
Two single nucleotide polymorphisms (SNPs) in the CD40 gene, rs1883832 and rs4810485, are associated with susceptibility to inflammatory and autoimmune diseases and are thought to alter CD40 expression at the mRNA and protein level.
|
27813548 |
2016 |
|
Recurrent aphthous ulcer
|
|
0.010 |
GeneticVariation
|
BEFREE |
To our knowledge, this is the first study regarding CD40 gene rs4810485 and rs1883832 mutations investigated in RAS patients.
|
27875792 |
2017 |
|
Lupus Erythematosus, Systemic
|
|
0.060 |
GeneticVariation
|
BEFREE |
This study aimed to evaluate the association of CD40 polymorphisms (-1 C > T, rs1883832 and 6,048 G > T, rs4810485) with SLE susceptibility, as well as with mRNA expression and soluble CD40 (sCD40) levels.
|
31642196 |
2019 |
|
Ischemic stroke
|
|
0.030 |
GeneticVariation
|
BEFREE |
This meta-analysis provided evidence of association of rs1883832 C allele with an overall increased risk of atherosclerosis but distinct effect of C allele on CAD (including ACS) and IS in Chinese population, respectively.
|
24828072 |
2014 |
|
Acute Chest Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
This meta-analysis provided evidence of association of rs1883832 C allele with an overall increased risk of atherosclerosis but distinct effect of C allele on CAD (including ACS) and IS in Chinese population, respectively.
|
24828072 |
2014 |
|
Coronary Artery Disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
This meta-analysis provided evidence of association of rs1883832 C allele with an overall increased risk of atherosclerosis but distinct effect of C allele on CAD (including ACS) and IS in Chinese population, respectively.
|
24828072 |
2014 |
|
Arteriosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
This meta-analysis provided evidence of association of rs1883832 C allele with an overall increased risk of atherosclerosis but distinct effect of C allele on CAD (including ACS) and IS in Chinese population, respectively.
|
24828072 |
2014 |
|
Atherosclerosis
|
|
0.020 |
GeneticVariation
|
BEFREE |
This meta-analysis provided evidence of association of rs1883832 C allele with an overall increased risk of atherosclerosis but distinct effect of C allele on CAD (including ACS) and IS in Chinese population, respectively.
|
24828072 |
2014 |
|
Rheumatoid Arthritis
|
|
0.730 |
GeneticVariation
|
BEFREE |
These results suggest that the CD40 SNPs rs1883832 and rs4810485 are not RA susceptibility markers in the western Mexican population.
|
27813548 |
2016 |
|
Osteoarthritis, Knee
|
|
0.010 |
GeneticVariation
|
BEFREE |
These data provide evidences that rs4810485 G > T and rs1883832 C > T in the CD40 gene may be associated with disease susceptibility and severity in KOA.
|
28320398 |
2017 |
|
Lupus Erythematosus, Systemic
|
|
0.060 |
GeneticVariation
|
BEFREE |
There were significant differences in the genotype and allele frequencies of CD40 gene rs1883832C/T polymorphism between the group of patients with SLE and the control group (P < 0.05). sCD40 levels were increased in patients with SLE compared with controls (P < 0.01).
|
26474561 |
2015 |
|
Lupus Erythematosus, Systemic
|
|
0.060 |
GeneticVariation
|
BEFREE |
The study did not prove CD40 gene (rs1883832 C/T) polymorphism as a clear risk factor of SLE in this cohort of Egyptian patients, though it was highly likely associated with the carriers of T allele.
|
30374748 |
2019 |
|
Behcet Syndrome
|
|
0.030 |
GeneticVariation
|
BEFREE |
The results suggest that TT genotypes of rs4810485 and rs1883832 may be predisposing genotypes for BD, and that the rs4810485 GT genotype may be a protective genotype for BD.
|
22087016 |
2012 |
|
Septicemia
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results showed that the frequencies of the TT genotype and the <i>CD40</i> rs1883832 T allele were significantly higher in sepsis patients than in healthy controls.
|
29780830 |
2018 |
|
Sepsis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The results showed that the frequencies of the TT genotype and the <i>CD40</i> rs1883832 T allele were significantly higher in sepsis patients than in healthy controls.
|
29780830 |
2018 |
|
Crohn Disease
|
|
0.720 |
GeneticVariation
|
BEFREE |
The impact of CD40 rs1883832 on MS and CD risk points to a common signaling shared by these autoimmune conditions.
|
20634952 |
2010 |
|
Multiple Sclerosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The impact of CD40 rs1883832 on MS and CD risk points to a common signaling shared by these autoimmune conditions.
|
20634952 |
2010 |
|
Acute Chest Syndrome
|
|
0.020 |
GeneticVariation
|
BEFREE |
The distribution of the rs1883832 genotypes (CC, CT, and TT) was 33.1%, 54.4%, and 12.5% in the ACS group and 22.8%, 53.3%, and 23.9% in controls, respectively.
|
21091218 |
2011 |
|
Malignant tumor of cervix
|
|
0.010 |
GeneticVariation
|
BEFREE |
The data from our study indicates a potential association between the rs1883832 and rs3765459 CD40 gene polymorphism and susceptibility to cervical cancer.
|
28181356 |
2017 |